反応 #64426

反応方程式

1-bromopentane

3-Bromophenol

potassium carbonate

→

3-bromo-phenol

n-pentyl ether

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度cooled to room temperature
2. 2
   ろ過filtered
3. 3
   workup.ADDITIONThe filtrate is diluted with ether
4. 4
   洗浄washed with water and brine
5. 5
   乾燥After drying over magnesium sulfate
6. 6
   濃縮concentrating
7. 7
   その他the crude oil obtained
8. 8
   その他is chromatographed over silica gel
9. 9
   洗浄eluted with 3:2 hexane

実験手順

To a solution of 5.0 gm of 3-Bromophenol in 60 mls of dimethylformamide is added 6.0 gm of potassium carbonate followed by 4.3 ml of 1-bromopentane. This mixture is heated to 60° C. for 6 hours and then cooled to room temperature and filtered. The filtrate is diluted with ether and washed with water and brine. After drying over magnesium sulfate and concentrating, the crude oil obtained is chromatographed over silica gel, and eluted with 3:2 hexane:ether to yield 3-bromo-phenol, n-pentyl ether as a clear oil.

出典