反応 #64418
ord-23b48d1c4eb04d21a12c78419eafc48f
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1温度is cooled in an ice bath
- 2その他The solvent is removed under vacuum
- 3その他The residue obtained
- 4その他chromatographed on normal phase silica gel eluting with a 3:2 ratio of hexane
実験手順
A mixture of 0.80 g of 60% NaH in 28 ml of anhydrous dimethylformamide is cooled in an ice bath. To this is added 3.01 g of the above 3-pentyloxyphenol oil dissolved in 7 ml of anhydrous dimethylformamide. This mixture is then stirred at room temperature for 45 minutes; 1.81 ml of 3-Bromopropanol are added; and the resultant mixture is stirred at 60° C. for 17 hours. The solvent is removed under vacuum, and the residue worked up in same manner as above. The residue obtained is flash chromatographed on normal phase silica gel eluting with a 3:2 ratio of hexane:ether to yield 3-[3-(pentyloxy)phenoxy]propanol as a pale yellow oil.