反応 #64417

反応方程式

1-Bromopentane

resorcinol

potassium carbonate

→

3-pentyloxyphenol

溶媒

dimethylformamide

反応条件

後処理

1. 1
   ろ過This mixture is filtered through Celite
2. 2
   濃縮concentrated under vacuum
3. 3
   抽出extracted 3 times with ether
4. 4
   洗浄The combined extracts are washed with saturated sodium chloride
5. 5
   乾燥dried over magnesium sulfate
6. 6
   ろ過filtered
7. 7
   濃縮concentrated under vacuum
8. 8
   その他chromatographed on normal phase silica gel eluting with a 4:1 ratio of hexane

実験手順

A mixture of 24.8 ml of 1-Bromopentane, 66.0 g of resorcinol, and 41.5 g of potassium carbonate is stirred in 400 ml of anhydrous dimethylformamide at 60° C. for 17 hours. This mixture is filtered through Celite and concentrated under vacuum. The residue is taken up in water and extracted 3 times with ether. The combined extracts are washed with saturated sodium chloride, dried over magnesium sulfate, filtered, and concentrated under vacuum. The residue is flash chromatographed on normal phase silica gel eluting with a 4:1 ratio of hexane:ether to yield 3-pentyloxyphenol as a clear oil.

出典