反応 #6432

反応方程式

sodium azide

oxaphosphorinane

2-phenoxy-2-oxo-6-iodomethyl-1,2-oxaphosphorinane

→

2-phenoxy-2-oxo-6-(azidomethyl)-1,2-oxaphosphorinane

収率 96.0%

溶媒

benzene DMF

反応条件

実験手順

A suspension containing two equivalents of sodium azide, one equivalent of the above-prepared iodonated oxaphosphorinane and a catalytic amount of about 0.1 equivalent of tetrabutylammonium bromide in benzene/DMF (1:1) was heated to 60-80 degrees C. for 16 hours to produce 2-phenoxy-2-oxo-6-(azidomethyl)-1,2-oxaphosphorinane in 96 percent yield as a white solid.

出典