反応 #643145

反応方程式

Clopidogrel

p-Toluene sulphonic acid

diethyl ether

→

Clopidogrel tosylate

溶媒

methanol

反応条件

後処理

1. 1
   温度The reaction mixture was heated
2. 2
   温度to reflux temperature for 2 hrs
3. 3
   ろ過The solid was filtered
4. 4
   その他dried at about 50° C. in a vacuum oven

実験手順

Clopidogrel base was dissolved in methanol. p-Toluene sulphonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 hrs. The solution was cooled to room temperature and was added drop-wise to diethyl ether. The suspension was stirred at RT. The solid was filtered and dried at about 50° C. in a vacuum oven to give Clopidogrel tosylate similar to that obtained above.

出典