反応 #6431

反応方程式

hydrochloric acid

glutaric anhydride

N-hydroxysuccinimide

triethylamine

→

mono N-hydroxysuccinimide glutarate

溶媒

dichloromethane

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate

実験手順

One mole of glutaric anhydride and one mole of N-hydroxysuccinimide were treated in dichloromethane with 1.2 equivalents of triethylamine. This reaction was stirred for 40 minutes, acidified by the addition of 0.5N hydrochloric acid (HCl) (aqueous), and then extracted with ethyl acetate to form mono N-hydroxysuccinimide glutarate. This glutarate was then combined with 5 moles of thionyl chloride and stirred at room temperature for three hours. The resulting reaction mixture was dried to remove volatiles, and thereby form N-hydroxysuccinimidyl glutaryl chloride.

出典