反応 #64309

反応方程式

1-cyano-2-methoxybenzene

tributyltin azide

→

5-(2-methoxyphenyl)-2H-tetrazole

収率 98.1%

溶媒

diethyl ether

xylene

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for hours
3. 3
   温度The reaction mixture then was cooled
4. 4
   その他Anhydrous hydrochloric acid was bubbled into the mixture
5. 5
   その他a white precipitate formed
6. 6
   ろ過The precipitate was collected by suction filtration
7. 7
   洗浄washed repeatedly with diethyl ether
8. 8
   その他Drying

実験手順

A mixture of 1-cyano-2-methoxybenzene (1.02 g, 7.7 mmol) and tributyltin azide (3.4 g, 10.0 mmol) in 3.0 mL of xylene was heated under reflux for hours. The reaction mixture then was cooled and diluted with diethyl ether. Anhydrous hydrochloric acid was bubbled into the mixture and a white precipitate formed. The precipitate was collected by suction filtration and washed repeatedly with diethyl ether. Drying gave 5-(2-methoxyphenyl)-2H-tetrazole (1.33 g, 7.55 mmol).

出典