反応 #642947

ord-189c3150e85940a183f9c2551a7dc7c7

反応方程式

c1ccc(CCN2CCNCC2)nc1
1-(2-Pyridin-2-yl-ethyl)-piperazine
N#CCBr
bromoacetonitrile
N#CCN1CCN(CCc2ccccn2)CC1
title compound
N#CCN1CCN(CCc2ccccn2)CC1
[4-(2-Pyridin-2-yl-ethyl)-piperazin-1-yl]acetonitrile

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他analogously to the preparation of Intermediate 149.2 as a colorless oil

実験手順

The title compound is synthesized by coupling of 1-(2-Pyridin-2-yl-ethyl)-piperazine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=231.2: CtRet=2.17.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08053457B2uspto-grants-2011_11