反応 #64235

反応方程式

sodium hydride

8-hydroxy-7-methoxy-1-octene

tosylate

1-hexadecanol

→

title compound

8-(Hexadecyloxy)-7-methoxy-1-octene

溶媒

water

dimethylformamide

dimethylformamide

反応条件

後処理

1. 1
   抽出extracted with ether
2. 2
   乾燥The ether solution was dried
3. 3
   その他evaporated
4. 4
   その他The residue was purified by chromatography

実験手順

To a suspension of 7.4 g of 60% sodium hydride in 100 ml of dimethylformamide was added a solution of 8-hydroxy-7-methoxy-1-octene in 150 ml of dimethylformamide over 1.5 hours. A 63.4 g portion of the tosylate of 1-hexadecanol was added and the mixture was stirred for 18 hours, poured into water and extracted with ether. The ether solution was dried and evaporated. The residue was purified by chromatography giving 41.5 g of the title compound as a oil.

出典