反応 #642204

反応方程式

Boc-L-Arg-OH

H-L-Trp-OBzl hydrochloride

HOBt

DIPEA

HBTU

→

yellowish solid

収率 123.5%

Boc-L-Arg-L-Trp-OBzl

収率 123.5%

溶媒

DMF

dichloromethane

反応条件

後処理

1. 1
   その他Evaporation

実験手順

To a stirred solution of Boc-L-Arg-OH (792 mg, 2.75 mmoles), H-L-Trp-OBzl hydrochloride (832 mg, 2.5 mmoles), HOBt (1378 mg, 9 mmoles) and DIPEA (2.05 ml, 12 mmoles) in DMF (6 ml) and dichloromethane (3 ml) cooled on ice was added HBTU (1138 mg, 3 mmoles) in small portions over 10 minutes. The mixture was stirred on ice for 45 minutes and at room temperature for 45 minutes. Workup was performed as described for KP-2-1. Evaporation afforded 1.7 g of a yellowish solid.

出典