反応 #64204

反応方程式

cyclopentanone

sodium hydride

5-bromomethylthiophene-2-carbonitrile

triethyl phosphite

→

5-cyclopentylidenemethylthiophene-2-carbonitrile

溶媒

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   その他Then triethyl phosphite is removed at 40°-60°/0.06 mbar
2. 2
   workup.DISTILLATIONthe residue is distilled on a bulb tube at 130°-150°/0.004 mbar
3. 3
   その他resulting in 24 g of (5-cyano-2-thienyl)methylphosphonic acid diethyl ester
4. 4
   workup.ADDITIONthe mixture is poured on water
5. 5
   抽出extracted with ethyl acetate
6. 6
   乾燥The ethyl acetate phase is dried
7. 7
   その他evaporated
8. 8
   その他the residue is recrystallized from isopropanol

実験手順

In a second process, 20 g of 5-bromomethylthiophene-2-carbonitrile is heated with 200 ml of triethyl phosphite for 4 hours to 150°. Then triethyl phosphite is removed at 40°-60°/0.06 mbar, and the residue is distilled on a bulb tube at 130°-150°/0.004 mbar, resulting in 24 g of (5-cyano-2-thienyl)methylphosphonic acid diethyl ester. Of this product, 5 g is added dropwise, with 1.5 ml of cyclopentanone in 5 ml of tetrahydrofuran, to a suspension of 581 mg of sodium hydride/oil (80% strength) and 116 mg of 15-crown-5 in 5 ml of tetrahydrofuran. After 2 hours of agitation at room temperature, the mixture is poured on water and extracted with ethyl acetate. The ethyl acetate phase is dried and evaporated, and the residue is recrystallized from isopropanol, thus obtaining 3.0 g of 5-cyclopentylidenemethylthiophene-2-carbonitrile, identical to the product described above.

出典