反応 #64197

反応方程式

adamantanone

lithium diisopropylamide

4-[1-(1,2,4-triazolyl)methyl]benzonitrile

water

→

4-(2-hydroxyadamant-2-yl-1(1,2,4-triazolyl)methyl]benzonitrile

収率 99.1%

溶媒

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   温度heated to 25°
2. 2
   抽出the mixture is extracted twice with ethyl acetate
3. 3
   洗浄washed neutral with water
4. 4
   乾燥dried over sodium sulfate
5. 5
   濃縮concentrated to dryness under vacuum

実験手順

5 g of 4-[1-(1,2,4-triazolyl)methyl]benzonitrile is dissolved in 100 ml of tetrahydrofuran and combined at -50° with 19.8 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran, stirred for 0.5 hour, further stirred with 4.25 g of adamantanone for 1 hour at -70°, and heated to 25°. Then water is added, the mixture is extracted twice with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, yielding 9 g of crude 4-(2-hydroxyadamant-2-yl-1(1,2,4-triazolyl)methyl]benzonitrile.

出典