反応 #6411

反応方程式

sodium hydroxide

8-bromo-1-octene

ethyl p-hydroxybenzoate

potassium carbonate

hydrochloric acid

→

p-(7-octenyloxy)benzoic acid

収率 89.0%

溶媒

water

ethanol

反応条件

後処理

1. 1
   workup.ADDITIONThereto added
2. 2
   温度reflux
3. 3
   その他After conclusion of the reaction
4. 4
   その他The generated precipitate was collected
5. 5
   洗浄washed sufficiently with water
6. 6
   その他dried
7. 7
   その他to obtain 10.8 g of the objective ether compound

実験手順

9.4 g of 8-bromo-1-octene, 9.0 g of ethyl p-hydroxybenzoate, and 7.6 g of potassium carbonate were refluxed in ethanol for 10 hours. Thereto added was an aqueous solution containing 2.4 g of sodium hydroxide, and then reflux was further continued for 10 hours. After conclusion of the reaction, the reaction solution was diluted with water, and the pH of the solution was lowered to 2 by dropping hydrochloric acid. The generated precipitate was collected, washed sufficiently with water, and dried, to obtain 10.8 g of the objective ether compound. (Yield: 89%)

出典