反応 #64082

反応方程式

(2R, 5S, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one

sulfuric acid

2-propanol

→

isopropyl (2S, 3R)-2-methyl-3-hydroxybutanoate

溶媒

water

反応条件

後処理

1. 1
   抽出followed by ether extraction
2. 2
   乾燥The ether phase was dried over anhydrous sodium sulfate and ether
3. 3
   workup.DISTILLATIONwas distilled off
4. 4
   workup.DISTILLATIONthe residue was subjected to distillation

実験手順

To 1.0 g of (2R, 5S, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one obtained by procedure similar to Example 1-(4) were added 0.1 ml of concentrated sulfuric acid and 10 ml of 2-propanol, stirred at room temperature for one hour, and 20 ml of water was added followed by ether extraction. The ether phase was dried over anhydrous sodium sulfate and ether was distilled off, and then the residue was subjected to distillation to obtain 0.4 g of isopropyl (2S, 3R)-2-methyl-3-hydroxybutanoate. ##STR41##

出典