反応 #64081

反応方程式

(2R, 5R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one

sulfuric acid

2-propanol

→

isopropyl (2R, 3R)-2-methyl-3-hydroxybutanoate

溶媒

water

反応条件

後処理

1. 1
   抽出ether extraction
2. 2
   乾燥After drying the ether phase over anhydrous sodium sulfate
3. 3
   workup.DISTILLATIONthe ether was distilled off
4. 4
   workup.DISTILLATIONthe residue was subjected to distillation

実験手順

To 1.0 g of (2R, 5R, 6R)-2-trichloromethyl-5,6-dimethyl-1,3-dioxan-4-one obtained by procedures similar to (1)-(4) of Example 1 were added 0.1 ml of concentrated sulfuric acid and 10 ml of 2-propanol and stirred at room temperature for one hour, and 20 ml of water was added to effect ether extraction. After drying the ether phase over anhydrous sodium sulfate, the ether was distilled off and the residue was subjected to distillation to give 0.4 g of isopropyl (2R, 3R)-2-methyl-3-hydroxybutanoate. The NMR chart is shown in FIG. 6. ##STR31##

出典