反応 #640575

反応方程式

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

ammonium chloride

water

→

3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one

収率 99.3%

溶媒

ethanol

反応条件

後処理

1. 1
   温度to reflux for 1.5 hours
2. 2
   ろ過the reaction mixture was filtered with suction
3. 3
   抽出extracted with ethyl acetate
4. 4
   洗浄The organic layer was washed with a saturated brine
5. 5
   乾燥dried over anhydrous sodium sulfate

実験手順

3-(2-Nitrobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.59 g, 5.10 mmol), iron powder (1.42 g, 25.4 mmol), ammonium chloride (0.14 g, 2.62 mmol) were suspended in ethanol (30 ml) and water (15 ml) and heated to reflux for 1.5 hours. After cooling to room temperature, the reaction mixture was filtered with suction and extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and 3-(2-aminobenzyl)-6-phenyl-[1,3]-oxazinan-2-one (1.43 g) was obtained by evaporating the solvent under reduced pressure.

出典