反応 #640552

反応方程式

thionyl chloride

trans-4-pentylcyclohexanecarboxylic acid

pyridine

→

trans-4-pentylcyclohexanecarboxylic acid chloride

溶媒

toluene

反応条件

後処理

1. 1
   温度under heating to 80° C. or less for 1 hour
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

実験手順

20 mL of thionyl chloride was added dropwise to a mixture containing 20.0 g (0.1 mol) of trans-4-pentylcyclohexanecarboxylic acid represented by the following formula (b-i), 0.5 mL of pyridine and 300 mL of toluene in a nitrogen atmosphere, and the mixture was stirred under heating to 80° C. or less for 1 hour. The solvent was distilled off under reduced pressure to provide trans-4-pentylcyclohexanecarboxylic acid chloride.

出典