反応 #640541

反応方程式

6-aminonicotinic acid

ethanol

→

white solid

Ethyl 6-Aminonicotinate

反応条件

後処理

1. 1
   その他was bubbled in dry hydrochloric acid at 0° C.
2. 2
   温度the solution was refluxed until all the solids
3. 3
   workup.DISSOLUTIONdissolved
4. 4
   その他The solvents were removed under reduced pressure
5. 5
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
6. 6
   洗浄washed with saturated sodium bicarbonate, brine
7. 7
   濃縮concentrated

実験手順

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

出典