反応 #640533

反応方程式

4-[1-(3-methoxy-4-hydroxyphenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

DIPEA

methoxymethyl chloride

→

title compound

4-[1-(3-Methoxy-4-methoxymethoxy-phenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

溶媒

DMF

ethyl acetate

反応条件

後処理

1. 1
   洗浄washed with water
2. 2
   乾燥dried over sodium sulphate
3. 3
   ろ過Filtration of the sodium sulphate and concentration of the filtrate under reduced pressure

実験手順

A mixture of 4-[1-(3-methoxy-4-hydroxyphenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.10 g, 0.27 mmol), DIPEA and methoxymethyl chloride in dry DMF is stirred at room temperature for 14 hours. The reaction mixture is diluted with ethyl acetate, washed with water and dried over sodium sulphate. Filtration of the sodium sulphate and concentration of the filtrate under reduced pressure gives the title compound as colorless, pure solid, m.p. 190° C.

出典