反応 #640517

反応方程式

4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

sodium bicarbonate

hydroxylamine hydrochloride

→

title compound

4-[1-(4-Bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine oxime

溶媒

ethanol

反応条件

後処理

1. 1
   温度is refluxed for 20 hours
2. 2
   その他Partitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase
3. 3
   その他by drying
4. 4
   その他evaporation of the solvent
5. 5
   その他gives the crude product
6. 6
   その他Purification by chromatography on silicagel

実験手順

A mixture of 4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.083 g, 0.21 mmol, prepared according to Example 1), sodium bicarbonate (0.021 g, 0.25 mmol) and hydroxylamine hydrochloride (0.014 g, 0.21 mmol) in ethanol (5 ml) is refluxed for 20 hours. Partitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase followed by drying and evaporation of the solvent gives the crude product. Purification by chromatography on silicagel yields the title compound as an E/Z-mixture, m.p. 198-201° C.

出典