反応 #640516

反応方程式

Phenacylbromid

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

→

title compound

4-(1-Phenacyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

溶媒

DMF

ethyl acetate

反応条件

後処理

1. 1
   その他at room temperature
2. 2
   洗浄the organic phase is washed repeatedly with brine
3. 3
   その他Drying of the solvent
4. 4
   ろ過filtering
5. 5
   その他evaporation of the solvent under reduced pressure

実験手順

Phenacylbromid (0.1 g, 0.49 mmol) is added to an efficiently stirred suspension of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.1 g, 0.4 mmol) [A. V. Sergievskii, O. A. Krasnoshek, S. F. Mel'nikova, I. V. Tselinskii, Russian Journal of Organic Chemistry, 2002, 38, 915-917] and potassium carbonate (0.172 g, 1.24 mmol) in dry DMF (5 ml) at room temperature. After 4 hours the reaction mixture is diluted with ethyl acetate and the organic phase is washed repeatedly with brine. Drying of the solvent, filtering and evaporation of the solvent under reduced pressure gives the title compound in crude form. The title compound is obtained in pure form by chromatography over silicagel, m.p. 202-204° C.

出典