反応 #64018

反応方程式

1-(4-methoxyphenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

1-decene

1-octadecene

→

3-(4-Methoxyphenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-n-octylisoxazolidine

反応条件

後処理

1. 1
   その他Derivative 3 (R=4-OCH3, n=7) is prepared by a procedure similar to
2. 2
   workup.ADDITIONThe resulting diastereomeric mixture of cis- and trans-derivative 3 (R=4-OCH3, n=7)
3. 3
   その他is flash-chromatographed on neutral silica gel

実験手順

Derivative 3 (R=4-OCH3, n=7) is prepared by a procedure similar to that described in Example 1 by reacting 1-(4-methoxyphenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide (1: R=4-OCH3) with 1-decene (2: n=7). The resulting diastereomeric mixture of cis- and trans-derivative 3 (R=4-OCH3, n=7) is flash-chromatographed on neutral silica gel using chloroform-methanol (99:1 by volume) as eluent. Isomer A has a melting point of 89°-91° C. (ethyl acetate).

出典