反応 #64017

反応方程式

1-phenyl-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

1-(4-chlorophenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

1-octene

1-octadecene

→

3-Phenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-n-hexylisoxazolidine

反応条件

後処理

1. 1
   その他Derivative 3 (R=H, n=5) is prepared by a procedure similar to
2. 2
   その他is flash-chromatographed on neutral silica gel using as eluent a 98:2
3. 3
   workup.ADDITIONby volume mixture of chloroform-methanol

実験手順

Derivative 3 (R=H, n=5) is prepared by a procedure similar to that described in Example 1 by reacting 1-phenyl-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide (1: R=H) with 1-octene (2: n=5). The resulting cis- and trans-diastereomeric mixture of compound 3 (R=H, n=5) is flash-chromatographed on neutral silica gel using as eluent a 98:2 by volume mixture of chloroform-methanol. Isomer A has a melting point of 93°-99° C. (ethyl acetate).

出典