反応 #63933

反応方程式

N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide

thiosemicarbazide

→

yellow crystals

収率 44.8%

N-Ethyl-N-[3-(3-amino-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]propanamide

収率 44.8%

溶媒

ethanol

反応条件

後処理

1. 1
   workup.ADDITIONThe mixture was treated
2. 2
   その他the product chromatographed
3. 3
   その他Recrystalization of the product from dichloromethane-hexane

実験手順

A solution of 5.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.2 g thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was treated and the product chromatographed as described for Example 70. Recrystalization of the product from dichloromethane-hexane afforded 2.4 g yellow crystals, mp 199°-200° C.

出典