反応 #63859

反応方程式

acetic acid

(E)-4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide

diazomethane

→

(E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide

溶媒

methanol

反応条件

後処理

1. 1
   workup.WAITto stand at 0° C. for an hour
2. 2
   その他The resulting reaction mixture
3. 3
   その他was evaporated under reduced pressure
4. 4
   その他to give an oil which
5. 5
   その他was purified by preparative thin layer chromatography

実験手順

To (E)-4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide (37 mg) in methanol (5 ml) was added excess etheral diazomethane at -20° C. The resulting mixture was allowed to stand at 0° C. for an hour and then acetic acid was added thereto until the yellow color of the solution was discharged. The resulting reaction mixture was evaporated under reduced pressure to give an oil which was purified by preparative thin layer chromatography, developing with chloroform containing 5% methanol to give (E)-4-ethyl-2-methoxyimino-5-nitro-3-hexenamide (21.5 mg).

出典