反応 #63851

反応方程式

hydrochloric acid

N-[(E,E)-4-ethyl-2,4-hexadienoyloxy]succinimide

L-threonine

triethylamine

→

N-[(E,E)-4-ethyl-2,4-hexadienoyl]-L-threonine

収率 52.9%

溶媒

tetrahydrofuran

dimethylformamide

water

反応条件

後処理

1. 1
   抽出The resulting mixture was extracted with ethyl acetate
2. 2
   洗浄washed with water
3. 3
   乾燥dried over magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

実験手順

To a solution of N-[(E,E)-4-ethyl-2,4-hexadienoyloxy]succinimide (1.19 g) in a mixture of tetrahydrofuran (50 ml) and dimethylformamide (30 ml) was added a solution of L-threonine (2.38 g) and triethylamine (2.78 ml) in water (50 ml). The mixture was stirred at ambient temperature for 6 hours and then acidified with 1N hydrochloric acid. The resulting mixture was extracted with ethyl acetate, washed with water and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure to give N-[(E,E)-4-ethyl-2,4-hexadienoyl]-L-threonine (640 mg).

出典