反応 #63800

反応方程式

hydrochloric acid

[2-(2-amino-5-chlorophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

sodium methoxide

→

title compound

収率 91.5%

7-Chloro-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

収率 91.5%

溶媒

methanol

methanol

反応条件

後処理

1. 1
   温度The solution was refluxed for 3 hours under argon
2. 2
   ろ過The white precipitate was filtered
3. 3
   洗浄washed with water, methanol
4. 4
   その他dried in vacuo

実験手順

To a solution of [2-(2-amino-5-chlorophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester (23.2 g, 59.2 mmole) in methanol (200 ml) was added a 25% solution of sodium methoxide in methanol (16 ml, 69.97 mmole). The solution was refluxed for 3 hours under argon. The reaction was cooled to room temperature and treated with 200 ml of 1N hydrochloric acid. The white precipitate was filtered and washed with water, methanol, and dried in vacuo to yield 19.5 g of the title compound, melting point 189°-190.5° C.

出典