反応 #63716

反応方程式

N-Cbz-1-aminocyclopropane carboxylic acid

dicyclohexylcarbodiimide

dimethylaminopyridine

2,2,5,5-tetramethylcyclopentanol

→

N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester

溶媒

CH2Cl2

反応条件

後処理

1. 1
   workup.ADDITIONall at 0° C., is added, via an addition funnel
2. 2
   ろ過the mixture is filtered
3. 3
   洗浄the filtrate is washed with 5% HCl (1×50 ml), saturated NaHCO3 (1×50 ml), and water (1×50 ml)
4. 4
   その他The organic layer is separated
5. 5
   乾燥dried over MgSO4
6. 6
   その他evaporated

実験手順

To a stirred solution of N-Cbz-1-aminocyclopropane carboxylic acid in dry (CH2)2Cl2 containing dicyclohexylcarbodiimide and dimethylaminopyridine (DMAP), all at 0° C., is added, via an addition funnel, 2,2,5,5-tetramethylcyclopentanol dissolved in CH2Cl2. After stirring for 4 days, the mixture is filtered, and the filtrate is washed with 5% HCl (1×50 ml), saturated NaHCO3 (1×50 ml), and water (1×50 ml). The organic layer is separated, dried over MgSO4 and evaporated to yield N-Cbz-1-aminocyclopropanecarboxylic acid 2,2,5,5-tetramethylcyclopentyl ester.

出典