反応 #636666

反応方程式

Water

2-(9-bromo-6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile

2-methyl-3-butyn-2-ol

diisopropylamine

→

[9-chloro-6-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

溶媒

ethyl acetate

DMF

反応条件

後処理

1. 1
   温度then cooled to room temperature
2. 2
   その他the layers were separated
3. 3
   洗浄the organic phase is washed with brine
4. 4
   乾燥dried over magnesium sulphate and volatiles
5. 5
   その他are removed under reduced pressure
6. 6
   その他The crude mixture is then purified on silica gel using 50% hexane/ethyl acetate
7. 7
   その他The product is then recrystallized in THF
8. 8
   その他triturated in hot ethyl acetate/ether mixture

実験手順

To a solution of 13 g of 2-(9-bromo-6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile in 240 mL of DMF is added 5.5 mL of 2-methyl-3-butyn-2-ol, 2.0 g of tetrakis(triphenylphosphine)palladium, 1.1 g of copper iodide and 5.6 mL of diisopropylamine. The mixture is stirred at 55° C. for 1 hr then cooled to room temperature and diluted with ethyl acetate (250 mL). Water (250 mL) is added and the layers were separated, the organic phase is washed with brine, dried over magnesium sulphate and volatiles are removed under reduced pressure. The crude mixture is then purified on silica gel using 50% hexane/ethyl acetate. The product is then recrystallized in THF and triturated in hot ethyl acetate/ether mixture to afford 5.4 g of [9-chloro-6-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile as a light yellow solid. 1H NMR (Acetone-d6): 8.93 (s, 2H), 8.53 (m, 2H), 8.36 (d, 2H), 8.01 (t, 1H), 7.78 (d, 2H), 4.53 (s, 1H), 1.61 (s, 6H).

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