反応 #63654

反応方程式

methoxyacetic acid

methoxyacetyl chloride

carnitine chloride

→

methoxy acetyl carnitine chloride

収率 75.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他was brought to 40° C.
3. 3
   workup.STIRRINGunder stirring for seven days
4. 4
   ろ過the unreacted carnitine chloride was filtered off
5. 5
   workup.ADDITIONUpon addition of tert-butyl methyl ether an oil
6. 6
   その他precipitated
7. 7
   その他The oil precipitation
8. 8
   その他The oil which finally separated

実験手順

A mixture of methoxyacetic acid (3 ml; 0.04 moles) and methoxyacetyl chloride (3 ml; 0.03 moles) was kept under stirring at 30° C. for 2 hours. To this mixture carnitine chloride (4 g; 0.02 moles) which had been previously dried was added. The resulting mixture was brought to 40° C. and kept under stirring for seven days. The mixture was then taken up with acetonitrile and the unreacted carnitine chloride was filtered off. Upon addition of tert-butyl methyl ether an oil precipitated. The oil precipitation was repeated four times with acetonitrile/tert butyl methyl ether. The oil which finally separated was lyophilized. Four grams of methoxy acetyl carnitine chloride were thus obtained. Yield: 75%

出典