反応 #63583

反応方程式

1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-propanol

pyridine

thionyl chloride

→

1-(3-chloropropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran

溶媒

trichloromethane

反応条件

後処理

1. 1
   workup.ADDITIONThe reaction mixture was poured onto ice-water
2. 2
   その他The organic phase was separated
3. 3
   洗浄washed with a sodium hydrogen carbonate solution (10%)
4. 4
   その他dried
5. 5
   その他evaporated

実験手順

To a stirred solution of 24.2 parts of 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-propanol in 8 parts of pyridine and 90 parts of trichloromethane were added dropwise 12.1 parts of thionyl chloride. Upon completion, the whole was heated slowly to 50° C. and stirring at this temperature was continued for 3 hours. The reaction mixture was poured onto ice-water. The organic phase was separated, washed with a sodium hydrogen carbonate solution (10%), dried and evaporated, yielding 20 parts of 1-(3-chloropropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran as a residue (intermediate 12).

出典