反応 #63472

反応方程式

2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene

sodium carbonate

→

2-(3-pyridylmethyl)-6-acetylnaphthalene

収率 101.3%

溶媒

hydrochloric acid

反応条件

後処理

1. 1
   抽出extracted with methylene chloride
2. 2
   乾燥The organic layer was dried over sodium sulfate
3. 3
   その他the solvent removed under reduced pressure

実験手順

A solution of 150 mg of 2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene in 15 ml of 1N hydrochloric acid was allowed to stand for 3 hours at room temperature. The solution was neutralized with sodium carbonate and extracted with methylene chloride. The organic layer was dried over sodium sulfate and the solvent removed under reduced pressure to give 130 mg of 2-(3-pyridylmethyl)-6-acetylnaphthalene as an oil.

出典