反応 #63451

反応方程式

cyanogen bromide

6,7-dihydro-5H-dibenz[c,e]azepine

→

5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile

溶媒

chloroform

chloroform

反応条件

後処理

1. 1
   ろ過a small amount of the hydrobromide salt of the still unreacted azepine is filtered off
2. 2
   洗浄The filtrate is washed three times with water
3. 3
   乾燥dried over anhydrous sodium sulphate
4. 4
   その他evaporated

実験手順

A solution of 1.91 g of cyanogen bromide in 20 ml of chloroform is added dropwise at 5°-10° C. within 25 minutes to a solution, cooled to 5° C., of 7 g of 6,7-dihydro-5H-dibenz[c,e]azepine in 50 ml of chloroform. The reaction mixture is stirred for a further 1 hour and then a small amount of the hydrobromide salt of the still unreacted azepine is filtered off. The filtrate is washed three times with water, dried over anhydrous sodium sulphate and evaporated. There is obtained solid 5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile, m.p. 123°-126° C.

出典