反応 #6341

反応方程式

1,3-dibenzyloxypropan-2-ol

paraformaldehyde

Triethyl phosphite

→

title compound

Diethyl [2-benzyloxy-1-(benzyloxymethyl)ethoxy]methylphoshonate

溶媒

dichloromethane

ethyl acetate

反応条件

後処理

1. 1
   その他Dry HCl gas was bubbled through an ice-
2. 2
   乾燥The resulting solution was dried (MgSO4)
3. 3
   その他evaporated to dryness
4. 4
   その他to leave an oil
5. 5
   その他The liquid obtained
6. 6
   洗浄washed with sodium bicarbonate solution
7. 7
   洗浄The organic phase was washed with brine
8. 8
   乾燥dried (MgSO4)
9. 9
   その他evaporated
10. 10
    その他to give a mobile oil, which

実験手順

Dry HCl gas was bubbled through an ice-cooled solution of 1,3-dibenzyloxypropan-2-ol (25 g, 0.092 mol) and paraformaldehyde (2.75 g, 0.092 mol) in dry dichloromethane (100 ml) for 1 hour. The resulting solution was dried (MgSO4) and evaporated to dryness to leave an oil. Triethyl phosphite (15.7 ml, 0.092 mol) was added and the resulting mixture stirred and heated at 140° C. for 16 hours. The liquid obtained was dissolved in ethyl acetate and washed with sodium bicarbonate solution. The organic phase was washed with brine, dried (MgSO4) and evaporated to give a mobile oil, which was chromotographed in silica (hexane/ethyl acetate 50:50 as eluant) to give the title compound as a colourless, mobile oil (19.7 g, 51). IR: νmax (film) 3055, 3020, 2900, 2860, 1490, 1470, 1450, 1390, 1305, 1255, 1095, 1050, 1030, 970, 820, 770, 735, 700 cm-1. 1H NMR: δH (CDCl3) 1.3 (6H, t, J=7 Hz, P-(OCH2CH3)2), 3.6 (4H, d, 2×CH2OCH2Ph),3.8-4.05 (1H, m, CH), 4.05 (2H, d, J=9 Hz, OCH2P), 4.0-4.3 (4H, m, P-(OCH2CH3)2), 4.55 (4H, s, 2×OCH2Ph), 7.38 (10H, s, 2×Ph). C22H31PO6 requires: C, 62.54; H, 7.42. Found: C, 62.75, H, 7.61. m/z: C22H31PO6 requires 422.1858; observed (M+) 422.1864.

出典