反応 #63409

反応方程式

2-fluoro-5-methylnitrobenzene

1f

9-flouro-6-(4-methyl-1-piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

1,2,3,4-tetrahydroquinoline

→

1-(4-methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline

1-(2-amino-4-methylphenyl)-1,2,3,4-tetrahydroquinoline

反応条件

実験手順

Starting with 1,2,3,4-tetrahydroquinoline and 2-fluoro-5-methylnitrobenzene and following the steps of 1a to 1f of Example 2, one may obtain, in sequence, 1-(4-methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-amino-4-methylphenyl)-1,2,3,4-tetrahydroquinoline, N-[2-{1-(5-methylphenyl)-1,2,3,4 -tetrahydroquinolin-1-yl}]-4-methyl-1-piperazine carboxamide, and 10-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino-[1,8-ab][15]benzodiazepine.

出典