反応 #63311

反応方程式

2-(1-bromoethyl)-2-(5-bromo-6-methoxy-2-naphthyl)-4(R),5(R)-dicarboxy-1,3-dioxolane

sulphuric acid

→

2-bromo-1-(5-bromo-6-methoxy-2-naphthyl)-propan-1-one

収率 43.0%

反応条件

実験手順

A mixture of diastereoisomers of 2-(1-bromoethyl)-2-(5-bromo-6-methoxy-2-naphthyl)-4(R),5(R)-dicarboxy-1,3-dioxolane (RRS:RRR=93:7; 2.52 g; 5 mmoles) and 96% sulphuric acid (15 ml) is kept at 20° C. for 20 minutes. The reaction mixture is processed as described in Example 1. In this manner, pure 2-bromo-1-(5-bromo-6-methoxy-2-naphthyl)-propan-1-one is obtained (0.8 g; 2.15 mmoles; yield 43%).

出典