反応 #63224

反応方程式

monoacetyl-ethylenediamine

5-bromo-2-furancarboxylic acid chloride

→

N-(2-acetamino ethyl)-5-bromo-2-furancarboxamide

溶媒

methylene chloride

triethylamine

methylene chloride

反応条件

後処理

1. 1
   ろ過suction filtered
2. 2
   洗浄washed with methylene chloride

実験手順

A solution of 22.6 g of 5-bromo-2-furancarboxylic acid chloride in 100 ml of methylene chloride was added dropwise within 20 minutes at 0°-8° to a solution, pre-cooled to 0°, of 11.0 g of monoacetyl-ethylenediamine in 250 ml of methylene chloride and 18 ml of triethylamine. The reaction mixture was stirred at room temperature overnight, suction filtered and washed with methylene chloride. There was obtained N-(2-acetamino ethyl)-5-bromo-2-furancarboxamide as pale beige crystals, m.p. 175°-176°.

出典