反応 #632027

反応方程式

3-quinuclidinone

benzaldehyde

sodium hydroxide

→

(Z)-2-benzylidenequinuclidin-3-one

収率 91.2%

溶媒

ethanol

反応条件

後処理

1. 1
   温度was refluxed for 1.5 h
2. 2
   温度After the solution was cooled
3. 3
   その他the yellow precipitates
4. 4
   その他were collected
5. 5
   洗浄washed with ethanol
6. 6
   その他dried

実験手順

A mixture of 3-quinuclidinone (20.9 g, 167 mmol), benzaldehyde (17.7 g, 167 mmol), and one pellet of sodium hydroxide in 75 mL of ethanol was refluxed for 1.5 h. After the solution was cooled, the yellow precipitates were collected, washed with ethanol, and dried to give (Z)-2-benzylidenequinuclidin-3-one (32.5 g, yield: 91.2%, mp 130-132° C.).

出典