反応 #632012

反応方程式

chloromethyl methyl ether

HCl

cyclopropylsulfonylamine tert-butyl carbamate

n-butyllithium

→

desired product

1-methoxymethylcyclopropylsulfonylamine tert-butylcarbamate

溶媒

THF

反応条件

後処理

1. 1
   温度the mixture was slowly warmed to room temperature overnight
2. 2
   抽出was then extracted with ethyl acetate (4×50 mL portions)
3. 3
   乾燥The combined extracts were dried (MgSO4)
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

To a solution of cyclopropylsulfonylamine tert-butyl carbamate (1.0 g, 4.5 mmol) dissolved in THF (30 mL) cooled to −78° C. was added n-butyllithium (6.4 mL, 10.2 mmol, 1.6M in hexane) and the reaction mixture was stirred for 1 hour. To this solution was added a neat solution of chloromethyl methyl ether (0.40 mL, 5.24 mmol), and the mixture was slowly warmed to room temperature overnight. The solution pH was adjusted to 3 using 1N aqueous HCl and was then extracted with ethyl acetate (4×50 mL portions). The combined extracts were dried (MgSO4), filtered, and concentrated to provide the desired product as a waxy solid (1.20 g, 100%) which was taken directly into the next reaction without further purification: 1H NMR (CDCl3) δ 1.03 (m, 2H), 1.52 (s, 9H), 1.66 (m, 2H), 3.38 (s, 3H), 3.68 (s, 2H), 7.54 (s, 1H); 13C NMR (CDCl3) δ 11.37, 28.29, 40.38, 58.94, 73.43, 83.61, 149.57.

出典