反応 #632010

反応方程式

N-tert-butyl-(1-methyl)cyclopropylsulfonamide

methyl benzoate

→

N-tert-butyl-(1-benzoyl)cyclopropyl-sulfonamide

収率 66.0%

反応条件

後処理

1. 1
   その他This compound was obtained in 66% yield
2. 2
   その他The crude product was purified by column chromatography over SiO2 using 30% to 100% dichloromethane in hexane

実験手順

This compound was obtained in 66% yield using the procedure described for the synthesis of N-tert-butyl-(1-methyl)cyclopropylsulfonamide using 1.2 equivalents of methyl benzoate as the electrophile. The crude product was purified by column chromatography over SiO2 using 30% to 100% dichloromethane in hexane: 1H NMR (CDCl3) δ 1.31 (s, 9H), 1.52 (m, 2H), 1.81 (m, 2H), 4.16 (br s, 1H), 7.46 (m, 2H), 7.57 (m, 1H), 8.05 (d, J=8.5 Hz, 2H).

出典