反応 #631847

反応方程式

4,5-bis-(p-methoxyphenyl)-thiazoline-2-thione

allyl bromide

→

2-Allylthio-4,5-bis-(p-methoxyphenyl)-thiazole

溶媒

sodium hydroxide

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture is stirred at room temperature for 10 minutes
2. 2
   抽出extracted
3. 3
   workup.STIRRINGby shaking twice with 10 ml of toluene each time
4. 4
   洗浄the combined aqueous phases are washed twice with 5 ml of 2 N sodium hydroxide solution each time
5. 5
   乾燥dried over magnesium sulphate
6. 6
   濃縮concentrated by evaporation under reduced pressure
7. 7
   その他crystallised from hexane

実験手順

0.5 g of 4,5-bis-(p-methoxyphenyl)-thiazoline-2-thione are dissolved in 2.6 ml of 2 N sodium hydroxide solution while stirring. 0.367 g of allyl bromide is added, the mixture is stirred at room temperature for 10 minutes, extracted by shaking twice with 10 ml of toluene each time, the combined aqueous phases are washed twice with 5 ml of 2 N sodium hydroxide solution each time, dried over magnesium sulphate, concentrated by evaporation under reduced pressure and crystallised from hexane. 2-Allylthio-4,5-bis-(p-methoxyphenyl)-thiazole having a melting point of 57°-58° is obtained.

出典