反応 #6317

反応方程式

hydrochloric acid

2-aminobenzonitrile

cyclohexanone

hydrochloric acid

→

9-amino-1,2,3,4-tetrahydroacridine hydrate

収率 67.0%

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 3 days
3. 3
   その他The precipitate was collected
4. 4
   洗浄washed with 10% hydrochloric acid

実験手順

A mixture of 2-aminobenzonitrile (120 g), cyclohexanone (115.8 ml), conc hydrochloric acid (9.2 ml), and cuprous chloride (1.21 g) was heated under reflux for 3 days, with stirring. At the end of each 24 hr period, additional cuprous chloride (1.21 g) was added. At the end of the 3rd day, additional conc hydrochloric acid (47.3 ml) was added, and the mixture was cooled to ambient temperature. The precipitate was collected and washed with 10% hydrochloric acid to provide 160 g (67.0%) of 9-amino-1,2,3,4-tetrahydroacridine hydrate, mp 180°-185°.

出典