反応 #6316

反応方程式

2-aminobenzonitrile

1,3-cyclohexandione

→

2-(3-oxocyclohexen-1-yl)aminobenzonitrile

収率 93.0%

溶媒

water

反応条件

後処理

1. 1
   温度was heated to 40°
2. 2
   workup.STIRRINGThe mixture was stirred at 40° for 1 hr
3. 3
   ろ過The mixture was filtered
4. 4
   洗浄the filter cake was washed with water

実験手順

A mixture of 2-aminobenzonitrile (120 g) and 1,3-cyclohexandione (120 g) in water (400 ml) was heated to 40° and 4-methylbenzenesulfonic acid monohydrate (6.2 g) was added, with stirring. The mixture was stirred at 40° for 1 hr. The mixture was filtered, and the filter cake was washed with water to provide 200 g (93%) of 2-(3-oxocyclohexen-1-yl)aminobenzonitrile, mp 191.4°.

出典