反応 #63131

反応方程式

hydrochloric acid

3-tetradecylphenol

acetate

aluminum chloride

→

desired compound

1-(2-Hydroxy-4-tetradecylphenyl)ethanone

溶媒

ether

反応条件

後処理

1. 1
   温度to cool
2. 2
   抽出extracted several times with ether
3. 3
   洗浄washed with water, brine
4. 4
   その他dried
5. 5
   その他The crude material was chromatographed on silica gel
6. 6
   洗浄eluting with hexane:ethyl acetate (50:1)

実験手順

A 20 g portion of 3-tetradecylphenol, acetate was heated at 110° C. and 8.4 g of aluminum chloride was added in portions over a 3 hour period. The mixture was allowed to cool, then diluted with ether, poured onto ice containing 10 ml of concentrated hydrochloric acid and extracted several times with ether. The ether extracts were combined, washed with water, brine and dried. The crude material was chromatographed on silica gel, eluting with hexane:ethyl acetate (50:1), giving 15.8 g of the desired compound, mp 45°-46° C.

出典