反応 #631059

反応方程式

3-benzoyl-3-bromo-propionic acid

5-methyl-3,4,5,6-tetrahydro-s-triazine-2(1H)-thione

→

7-carboxymethyl-6-hydroxy-3-methyl-6-phenyl-3,4,6,7-tetrahydro-2H-thiazolo[3,2-a]-s-triazine hydrobromide

収率 90.7%

溶媒

—

solvent

methanol

反応条件

後処理

1. 1
   その他Evaporation of the solvent

実験手順

A solution of 3-benzoyl-3-bromo-propionic acid (6.4 g, 0.025 moles) in methanol (30 ml) was mixed with a solution of 5-methyl-3,4,5,6-tetrahydro-s-triazine-2(1H)-thione (3.27 g, 0.025 moles) in the same solvent (100 ml) and left for 3 hours. Evaporation of the solvent gave 7-carboxymethyl-6-hydroxy-3-methyl-6-phenyl-3,4,6,7-tetrahydro-2H-thiazolo[3,2-a]-s-triazine hydrobromide quarter hydrate as a pale yellow solid (8.8 g), m.p. 74°-77° C.

出典