反応 #63082

反応方程式

2,2,2-Trifluoroethylisothiocyanate

2,2,2-trifluoroethylamine hydrochloride

triethylamine

→

1,3-di(2,2,2-trifluoroethyl)thiourea

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他evaporated to dryness
2. 2
   その他The residue was partitioned between water and ethyl acetate
3. 3
   乾燥the ethyl acetate phase was dried
4. 4
   その他evaporated to dryness
5. 5
   その他The residue was recrystallised from a mixture of acetone and light petroleum ether (b.p. 60°-80°)

実験手順

2,2,2-Trifluoroethylisothiocyanate (2.12 g.) was added to a mixture of 2,2,2-trifluoroethylamine hydrochloride (1.36 g), triethylamine (1.01 g) and acetonitrile (10 ml.), and the mixture stirred at room temperature for 4 hours and then evaporated to dryness. The residue was partitioned between water and ethyl acetate, and the ethyl acetate phase was dried and evaporated to dryness. The residue was recrystallised from a mixture of acetone and light petroleum ether (b.p. 60°-80°) to give 1,3-di(2,2,2-trifluoroethyl)thiourea, m.p. 152°-153°.

出典