反応 #6308

反応方程式

Water

n-BuLi

4-(benzoxazol-2-yl)tolyltriphenylphosphonium bromide

3-(N-hydroxyhexyl-1,2,3,4-tetrahydroquinolin-6-yl)acrolein

→

1-(N-hydroxyhexyl-1,2,3,4-tetrahydroquinolin-6-yl)-4-(4-benzoxazol-ylphenyl)-1,3-butadiene

溶媒

toluene

toluene

反応条件

後処理

1. 1
   その他the solids are isolated by vacuum filtration
2. 2
   洗浄washed with 60% ethanol/water
3. 3
   その他dried under vacuum
4. 4
   その他The product is purified by recrystallization from benzene

実験手順

To a stirred mixture of 110 g (0.2 mole) of 4-(benzoxazol-2-yl)tolyltriphenylphosphonium bromide in toluene is added dropwise 0.2 mole of n-BuLi at room temperature. After 2 hours a solution of 28.7 g (0.1 mole) of 3-(N-hydroxyhexyl-1,2,3,4-tetrahydroquinolin-6-yl)acrolein in toluene is added dropwise to the mixture, and the reaction is stirred for 18 hours at room temperature. Water is added, and the solids are isolated by vacuum filtration, washed with 60% ethanol/water, and dried under vacuum. The product is purified by recrystallization from benzene.

出典