反応 #630547

ord-9f2bf8faa2b04c1fb43a61988fdfed31

反応方程式

O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CCCC[C@H]1C(=O)O
cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylic acid
CO.[Na+].[OH-]
NaOH methanol
→
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CCCC[C@H]1C(=O)[O-].[Na+]
sodium cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylate

反応物

O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CCCC[C@H]1C(=O)O
cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylic acid
CO.[Na+].[OH-]
NaOH methanol

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他The solvent was evaporated off to dryness

実験手順

10 m Mol of cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylic acid was dissolved in 100 ml of 0.1N NaOH/methanol solution. The solvent was evaporated off to dryness to give sodium cis-2-[(3,5-bistrifluoromethyl phenyl)-aminocarbonyl]-cyclohexane carboxylate [melting point: 259°-260° C. (decomposition)].

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04661630uspto-grants-1987_04