反応 #6302

反応方程式

1,2,3,4-tetrahydroquinoline

6-bromohexanol

potassium carbonate

→

N-Hydroxyhexyl-1,2,3,4-tetrahydroquinoline

溶媒

toluene

反応条件

後処理

1. 1
   その他the solids are removed by filtration
2. 2
   その他The solvent is removed in vacuo
3. 3
   その他the N-hydroxyhexyltetrahydroquinoline is purified by chromatography (silica gel, hexane:ethyl acetate)

実験手順

A stirred solution of 133.2 g (1 mole) of 1,2,3,4-tetrahydroquinoline, 181.1 g (1 mole) of 6-bromohexanol, and 138.2 g (1 mole) of potassium carbonate in toluene is heated at 80° C. for 3 hours. The solution is cooled to room temperature, and the solids are removed by filtration. The solvent is removed in vacuo, and the N-hydroxyhexyltetrahydroquinoline is purified by chromatography (silica gel, hexane:ethyl acetate).

出典