反応 #63002

ord-ea422ea6695c4f579e756504863a5c32

反応方程式

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC(C(C(=O)O)C(=O)O)[C@@H]2C(=O)CC1CCCCO1
( IX )
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC(C(C(=O)O)C(=O)O)[C@@H]2C(=O)CC1CCCCO1
21-tetrahydropyranyl-16-dicarboxymethyl-11β-hydroxy-3,20-dioxo-1,4-pregnadiene
CC(=O)OC(C)=O
acetic anhydride
→
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC(C(C(=O)O)C(=O)O)[C@@H]2C(=O)CO
21-acetoxy-16α-methoxycarbonyl-11β-hydroxy-3,20-dioxo-1,4-pregnadiene
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC(C(C(=O)O)C(=O)O)[C@@H]2C(=O)CO
11β,21-dihydroxy-16-dicarboxymethyl-3,20-dioxo-1,4-pregnadiene

反応物

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC(C(C(=O)O)C(=O)O)[C@@H]2C(=O)CC1CCCCO1
( IX )
C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC(C(C(=O)O)C(=O)O)[C@@H]2C(=O)CC1CCCCO1
21-tetrahydropyranyl-16-dicarboxymethyl-11β-hydroxy-3,20-dioxo-1,4-pregnadiene
CC(=O)OC(C)=O
acetic anhydride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The process of claim 12 which additionally comprises reacting (IX) with acetic anhydride to produce (X) 21-acetoxy-16α-methoxycarbonyl-11β-hydroxy-3,20-dioxo-1,4-pregnadiene.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04762919uspto-grants-1988_08